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5908: Cross-sectional study examining and comparing the clinical impact of the otolaryngological manifestations of primary ciliary dyskinesia and primary immunodeficiencies

Summary

A collaboration between pulmonologists, immunologists, and otolaryngologists at four sites, this project is designed to comprehensively define and compare the clinical manifestations and morbidity of upper airway involvement in primary ciliary dyskinesia and primary immunodeficiencies. The main objective of this project is to collect critical data to inform the design of future clinical trials that treat upper airway disease in these conditions. This one-visit study will include a comprehensive medical history, targeted ENT physical, nasal endoscopy, mucus sample collection, nasal nitric oxide, smell identification testing, audiology assessment and a sinus CT.

Recruiting

Participating Sites

555 University Avenue
Toronto, Ontario, Canada, M5G 1X8
https://www.sickkids.ca/


Contact:
Principal Investigator: Felix Ratjen, MD, PhD, FRCP, (C)FERS

+1 416 813 6167

felix.ratjen@sickkids.ca


Co-Investigator: Nikolaus Wolter, MD, MSc, FRCSC, FACS


Co-Investigator: Sharon Cushing, MD, MSc, FRCSC


Co-Investigator: Eyal Grunebaum, MD


Clinical Research Nurse Specialist: Sheryl Hewko

+1 416 813 7865 ext 307865

sheryl.hewko@sickkids.ca

845 Sherbrooke Street W
Montreal, Quebec, Canada, H3A 0G4
https://www.mcgill.ca/


Contact:
Site Principal Investigator: Adam J. Shapiro, MD

+1 514 412 4444

adam.shapiro@muhc.mcgill.ca


Co-Investigator: Donald Vinh, MD


Co-Investigator: Reza Alizadehfar, MD


Co-Investigator: Sam J. Daniel, MD


Co-Investigator: Marc Tewfik, MD


Co-Investigator: Joshua Gurberg, MD

Sandra Pepin, RN

Mylène Roy, PDt, CCRP

101 Manning Drive
Chapel Hill, North Carolina, United States, 27514
https://www.unc.edu/


Contact:
Principal Investigator: Stephanie D. Davis, MD


Co-Investigator: Thomas Ferkol, MD

+1 314 454 2694

thomas_ferkol@med.unc.edu


Co-Investigator: Michael Knowles, MD


Co-Investigator: Margaret Leigh, MD


Co-Investigator: Maimoona Zariwala, PhD


Co-Investigator: Adam Kimple, MD, PhD


Co-Investigator: Eveline Wu, MD


Co-Investigator: Tim Vece, MD


Co-Investigator: Leigh Anne Daniels, MD, MPH


Project Officer: Kelli M. Sullivan, MPH

+1 919 962 9786

kelli_sullivan@med.unc.edu


Co-Investigator: Kenneth Olivier, MD, MPH

1 Brookings Drive
St. Louis, Missouri, United States, 63130
https://wustl.edu/


Contact:
Principal investigator: Amjad Horani, MD

horani_a@wustl.edu


Research Coordinator: Jane Quante, RN

+1 314 454 2353